Born in 1986 in London. He received his general education at Eton College and completed a bachelor's degree in music theory from the University of Cambridge. In 1998–2004 studied violin in  Royal College of Music in London (class of Yitzhak Rashkovsky), then improved under the guidance of Shlomo Mintz.

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Performs with the world's leading orchestras and outstanding conductors, including Charles Duthoit, Edward Gardner, Zubin Mehta, Yannick Nézet-Séguin, Roger Norrington, Libor Peshek, Yuri Simonov. Participated in festivals in Spoleto, St. Moritz, Gstaad, Bergen, Windsor, Tine@Munch in Oslo, etc. Charlie Siem's regular duet partner is the famous pianist Itamar Golan, with whom the violinist has performed in many countries around the world.

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The musician's discography includes albums released by Warner Classics and Sony Classical (the artist has an exclusive contract with the latter) and recorded, in particular, with the London Symphony Orchestra,  Munich Radio, pianist Andrey Korobeinikov and others.

He is a representative of the charitable organization The Prince's Trust, a visiting professor at the College of Music in Leeds (UK) and the University of the Arts in Nanjing (PRC). In the 2016/17 season, he made a big tour of China and was named the "Ambassador of Nanjing Culture".

He gives master classes around the world at renowned educational institutions, including the Royal College of Music in London and the Academy of Music in Florence.

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Fascinated by the idea of expanding the violin repertoire in the modern world, Charlie Siem continued the long tradition of composing virtuoso variations on popular musical themes, which he performed with Bryan Adams, Jamie Cullum and The Who. In 2014 he wrote his first composition, Canopy for Violin and Strings, and recorded it with the English Chamber Orchestra. She also collaborates with fashion brands such as Armani, Chanel, Dior, Dunhill, Hugo Boss.

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Plays a D'Egville violin by Giuseppe Guarneri "del Gesu" (1735).